IP & Confidentiality
IP & Confidentiality
- Intonation is a dedicated contract research organization and does not undertake any internal drug discovery research.
- IP protection is our first and foremost priority and we have taken significant measures to follow the highest levels of data and confidentiality security
- All employees trained in IP awareness
- Confidentiality Disclosure Agreement (CDA) signed by all employees
- The client is the owner of all created Intellectual Property (IP)
- All project-specific data stored in dedicated places
- Computers are protected to prevent unauthorized access
Intonation Science
Intonation Science
With a team of over 175+ scientists that have published 280 papers and patents, delivered 16 INDs and 6 marketed drugs we know what it takes to be successful in drug discovery.
We are small enough to be flexible and nimble ensuring quick decision making and large enough to ensure we have the resources to deliver on the most challenging projects.
We have a highly talented scientific team with an average of more than 6 years of industrial experience and a ratio of Ph.D:M.Sc = 1:4
Our Infrastructure
We operate a 130,000 sq.ft state of the art chemistry and bioscience facility in Hyderabad India. The laboratory complex with 60 fume hoods, cell culture,
screening and radioisotope laboratories are designed to facilitate effective communication and workflow between scientists.
Years of Experience
Labs
Scientists
Research Reports
Every Chemistry laboratory is fully-equipped with:
- 10 chemical hoods
- 1X combi-flash
- 5X rotary evaporators
- Rx flasks from 5 ml to 25 lt capacity
- 1X dedicated LC/MS
- 1X microwave
- N2, air, vac lines
- 250 ml and 2.0 lt hydrogenation capacity
We can scale-up a compound up to 10kg per month depending on the number of steps. Our scale-up laboratory includes the following:
- 6 Walk-in Chemical Hoods
- 50 and 100 lt Rotavapors
- 1X 100 lt Glass Reactor
- 2X 50 lt Glass Reactors
Large-Scale Separation Capabilities include:
- Flash Column (Comp. air)
- Combiflash
- 4-40g (NP)
- 10-950g (RP)
- Monitoring by LC/MS, TLC All data archived
- MS assisted Prep
Bioscience Facilities
Bioscience Facilities
Our bioscience team’s principal role is to support our integrated discovery programs. Our bioscience knowledge of target biology, therapeutic area specialization, and ability to work collaboratively at each stage of the drug discovery process allows the efficient design or transfer and validation of high-quality single assays or cascades to accelerate your hit finding, hit-to-lead and lead optimization programs. We have the expertise and infrastructure to support biochemical, cell-based and radio-ligand binding assays.
IBSC (Institutional Bio-Safety Committee (IBSC)) Accreditation
The facility is an IBSC committee approved by the DBT (Department of Biotechnology, Government of India) nominated IBSC Nominee, DBT nominated outside expert and medical Safety Officer to review and approve the projects involving biological products or derived products.
Screening facility
- Victor X3 plate reader: Perkin Elmer
- Envision Plate reader: Perkin Elmer
- HTS Alpha screen compatible
- Biacore T200
- Two Multi Drops for dispensing: Thermo Fischer scientific
- Top count scintillation counter: Perkin Elmer
- Bio-rad gel running and blotting apparatus
- 8 channel and 12 channel Multichannel pipettes.
- -80 freezer and -20 freezers from Thermo Fischer scientific
- Four high-speed cold microcentrifuges
- Cell culture facility
- Two advanced C02 incubators: Thermo Fischer Scientific
- Microscope
- BS-I and BS-II laminar flows
- Water baths
- Autoclave machine
- Water bath sonicator
- ELISA and Activity Assays, MSD Assays, Laser Light Scattering with UV and RI (Static), FTIR
Analysis/ Bioanalysis
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Radio Isotope facility
A dedicated Type-II radioactive facility is established to handle UNSEALED RADIOISOTOPES. The radioactive lab is equipped to handle 3H, 32P, 14C, 35S. This facility works under the supervision of a dedicated Radiation safety officer (RSO). The facility was designed and constructed as per the AERB guidelines. The list of major equipment across all laboratories: