Team Lead – Biosciences

Intonation Research Laboratories is accelerating drug discovery and creating better therapeutics by supporting its clients in chemical synthesis, biochemical and cell-based assays, etc. We have assembled a diverse team with extensive experience across drug discovery disciplines. This continuum of complementary skills is essential for driving our scientific vision and needs to support our clients. We are a science-inspired, perseverant, synergistic, supportive, intrepid, and inclusive company. If you are inspired to bring better medicines to patients within a collaborative organization, then Intonation could be the right place for you.

• Design, execute, and independently run biochemical and biology experiments
• Critically analyze, interpret, and present data to the team
• Collaborate with senior researcher(s) to develop, optimize, validate, and automate biochemical and cellular assays to characterize small molecules inhibitors for hit-finding, hit-to-lead, and lead-optimization
• Communicate ideas and results to internal and external parties in verbal, written, and presentation formats
• Establish cellular models of disease and execute assays to evaluate drug activity and mechanism of action

• PhD in biology or related fields, with an emphasis on biochemistry, cell biology, and molecular biology with min 8+ years of experience.
• Demonstrated experience with biochemical and cell culture assays development, validation and miniaturisation for primary screen utilising different technologies (ex: SPA, HTRF, Alpha screen, Nano BRET, LANCE)
• Laboratory techniques such as ELISA, western blots, immunofluorescence, qPCR, and gene expression
• To perform enzymatic assays and MOA studies (mechanism of action) for lead compounds
• Understanding of Enzymology including enzyme kinetics.
• Strong ability to analyze and communicate complex data in a clear and concise manner
• Team player with excellent interpersonal skills and attention to detail